Ball point pen illustrator

http://www.creativetempest.com/illustration/andrea-joseph/ 

Use your mouse as a paint brush

http://www.stumbleupon.com/su/4gN8sC/www.zigzagphilosophy.com/

Sharpie Art on Styrofoam Cups

http://acidcow.com/pics/5231-sharpie-art-on-styrofoam-cups-79-pics.html